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Parathyroid glands exhibit reduced parenchymatic chief cells and increased extracellular collagen as a response to a long-term low- phosphorus diet in pigs
Autor: Michael Oster, Henry Reyer, Frieder Hadlich, Siriluck Ponsuksili, Petra Wolf, Klaus Wimmers, Jonas Keiler
In:
Animal Nutrition
ISBN: 2405-6545
Seite: 471 - 482
Jahr: 2025
Einordung:
Institut: Professur Tierzucht und Haustiergenetik
Abstract:
Parathyroid glands (PTG) are essential in maintaining mineral homeostasis, particularly in regulating
blood calcium (Ca) and phosphorus (P) levels. The endocrine regulation via parathyroid hormone (PTH)
is a prerequisite for the efficient utilization of dietary P. The PTG contain lobules of PTH-producing chief
cells surrounded by extracellular collagen. It is hypothesized that the areal proportions of chief cells and
extracellular collagen in PTG are dependent on dietary P intake. Based on PTG gene expression patterns,
a total of 18 crossbred pigs balanced for sex and litter were fed one of three long-term diets with low
(n = 6), medium (n = 6), or high P levels (n = 6) from weaning at d 28 until slaughter at d 120. Total
dietary P levels of low, medium, and high P groups were 5.20, 6.48 and 7.80 g/kg diet for grower,
respectively, and 4.12, 5.50 and 6.96 g/kg diet for fattener, respectively. The effects of P supply were
analyzed for their impact on the microscopic structure of porcine PTG using microphotographs
following Azan trichrome staining verified by immunohistochemistry of PTH, calcium-sensing receptor
(CaSR), collagen type I (COL1), and collagen type III (COL3) and related to gene expression data. His
tological stainings of PTG showed significantly reduced areas of PTG chief cells (P < 0.001) and increased
extracellular collagen (P < 0.001) in animals fed low dietary P compared to control and high P diets. The
long-term adaptation to a low P diet indicates a PTG reorganization and suggests that the lobular
structure, along with the extracellular matrix, may play a role in the complex processes of mineral
homeostasis. Mechanistically, this could be a component of a physiologic and possibly reversible
response following long-term P intake, which has implications for PTG regulation and, consequently,
PTH control. Ansprechpartner
Zur Publikation: Mitarbeiter,
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Letzte Änderung des Eintrages:
09.04.2026
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