Adrenal cortex expression quantitative trait loci in a German Holstein x Charolais cross.

Autor: Brand, Bodo; Scheinhardt, Markus O.; Friedrich, Juliane; Zimmer, Daisy; Reinsch, Norbert; Ponsuksili, Siriluck; Schwerin, Manfred; Ziegler, Andreas
In:

BMC Genetics

Bandangabe: 17
Auflage: 1
ISBN: 1471-2156
DOI: 10.1186/s12863-016-0442-x
Seite: 135

Einordung:
Institut: Professur Tierzucht und Haustiergenetik

Abstract:
The importance of the adrenal gland in regard to lactation and reproduction in cattle has been recognized early. Caused by interest in animal welfare and the impact of stress on economically important traits in farm animals the adrenal gland and its function within the stress response is of increasing interest. However, the molecular mechanisms and pathways involved in stress-related effects on economically important traits in farm animals are not fully understood. Gene expression is an important mechanism underlying complex traits, and genetic variants affecting the transcript abundance are thought to influence the manifestation of an expressed phenotype. We therefore investigated the genetic background of adrenocortical gene expression by applying an adaptive linear rank test to identify genome-wide expression quantitative trait loci (eQTL) for adrenal cortex transcripts in cattle.

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